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Total 24019 results found since Jan 2013.

BCL6B (B-Cell CLL/Lymphoma 6 Member B Protein) Contributes to Ocular Vascular Diseases via Notch Signal Silencing
CONCLUSIONS: These data indicate that BCL6B may be a novel therapeutic target for ocular vascular diseases characterized by ocular neovascularization and edema.PMID:37078291 | DOI:10.1161/ATVBAHA.123.318987
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2023 Category: Cardiology Authors: Miruto Tanaka Shinsuke Nakamura Tomohisa Sakaue Takumi Yamamoto Masashi Maekawa Anri Nishinaka Hiroto Yasuda Kaori Yunoki Yuji Sato Masaaki Sawa Kohichiro Yoshino Masamitsu Shimazawa Masahiko Hatano Takeshi Tokuhisa Shigeki Higashiyama Hideaki Hara Source Type: research

BMP (Bone Morphogenetic Protein) 9/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability.
CONCLUSIONS: From these data, we suggest that by preventing retinal vascular permeability, BMP9 could serve as a novel therapeutic agent for diabetic macular edema. PMID: 29880487 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 7, 2018 Category: Cardiology Authors: Akla N, Viallard C, Popovic N, Lora Gil C, Sapieha P, Larrivée B Tags: Arterioscler Thromb Vasc Biol Source Type: research

Intermedin Enlarges the Vascular Lumen by Inducing the Quiescent Endothelial Cell Proliferation.
CONCLUSIONS: Our findings suggest a novel mechanism that may explain how quiescent ECs overcome the contact inhibition and regain the ability to proliferate for continuous vascular lumen enlargement. PMID: 29242270 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 14, 2017 Category: Cardiology Authors: Wang LJ, Xiao F, Kong LM, Wang DN, Li HY, Wei YG, Tan C, Zhao H, Zhang T, Cao GQ, Zhang K, Wei YQ, Yang HS, Zhang W Tags: Arterioscler Thromb Vasc Biol Source Type: research

ALK1 (Activin-Receptor Like Kinase 1) Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K (Phosphatidylinositol 3-Kinase) Activation.
CONCLUSIONS: Overall, our results indicate that the BMP9/ALK1 hub critically mediates vascular quiescence by limiting PI3K signaling and suggest that PI3K inhibitors could be used as novel therapeutic agents to treat hereditary hemorrhagic telangiectasia. PMID: 29449337 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2018 Category: Cardiology Authors: Alsina-Sanchís E, García-Ibáñez Y, Figueiredo AM, Riera-Domingo C, Figueras A, Matias-Guiu X, Casanovas O, Botella LM, Pujana MA, Riera-Mestre A, Graupera M, Viñals F Tags: Arterioscler Thromb Vasc Biol Source Type: research

Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio).
Conclusions- Our study suggests a functional role for cilia in brain ECs, which is associated with the emergence and remodeling of the primary cranial vasculature. This cilia function is flow-independent, and cilia in ECs are required for cerebral-vascular stability. PMID: 30571172 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Eisa-Beygi S, Benslimane FM, El-Rass S, Prabhudesai S, Abdelrasoul MKA, Simpson PM, Yalcin HC, Burrows PE, Ramchandran R Tags: Arterioscler Thromb Vasc Biol Source Type: research

Increased Ephrin-B2 expression in pericytes contributes to retinal vascular death in rodents.
Abstract AIMS: Diabetes-induced retinal vascular cell death aggravates diabetic retinopathy (DR) to the proliferative stage and blindness. Pericytes play a crucial role in retinal capillaries survival, stability, and angiogenesis. Ephrin-B2 is a tyrosine kinase that regulates pericytes/endothelial cells communication during angiogenesis; yet, its role in DR is still unclear. We hypothesize that diabetes increases Ephrin-B2 signaling in pericytes, which contributes to inflammation and retinal vascular cell death. METHODS: Selective inhibition of the Ephrin-B2 expression in the retinal pericytes was achieved us...
Source: Vascular Pharmacology - June 21, 2020 Category: Drugs & Pharmacology Authors: Coucha M, Barrett AC, Bailey J, Abdelghani M, Abdelsaid M Tags: Vascul Pharmacol Source Type: research

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression.
CONCLUSIONS: Our study identifies molecular crosstalk between the Wnt/β-catenin and the Notch and VEGF-A signaling pathways and strongly suggest that endothelial β-catenin signaling supports central nervous system angiogenesis by promoting endothelial cell sprouting, tip cell formation, and VEGF-A/VEGFR2 signaling. PMID: 31533473 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 18, 2019 Category: Cardiology Authors: Martowicz A, Trusohamn M, Jensen N, Wisniewska-Kruk J, Corada M, Chenfei Ning F, Kele J, Dejana E, Nyqvist D Tags: Arterioscler Thromb Vasc Biol Source Type: research

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists
Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and...
Source: Journal of Vascular Research - February 24, 2023 Category: Research Source Type: research

Retinal Artery Occlusion Does Not Portend an Increased Risk of Stroke
The aim of this study was to determine the subsequent risk of stroke after a diagnosis of retinal artery occlusion (RAO). We hypothesized that the risk would be low and comparable to that of the general population. RAO is relatively rare and often incorrectly diagnosed. We believe our institution is in a unique position to investigate this relationship with both a high-volume eye center and vascular laboratory.
Source: Journal of Vascular Surgery - August 21, 2019 Category: Surgery Authors: David J. Laczynski, Sean P. Lyden, Joshua Gallop, James Bena, Francis J. Caputo Tags: Abstract from the 2019 Midwestern Vascular Surgical Society Annual Meeting Source Type: research